Purpose: This study aims to develop a durable closed-loop supply chain network capable of simultaneously addressing sustainability, resilience, agility, and digitalization while incorporating fuzzy–stochastic uncertainties. The significance of this research lies in the limitations of traditional supply chains, which often fail to perform effectively under severe environmental fluctuations, operational disruptions, and demand variability, thereby highlighting the need for intelligent and multidimensional decision-making frameworks.

Methodology: To achieve the research objectives, a structured three-phase framework was designed. In the first phase, demand—subject to considerable uncertainty—was forecast using the SARIMA time-series model to capture market volatility and seasonal patterns. In the second phase, supplier evaluation criteria were identified through a systematic literature review and expert judgment, and subsequently weighted via the stochastic–fuzzy Best–Worst Method (SFBWM). Supplier ranking was then performed using the stochastic–fuzzy TOPSIS (SFTOPSIS) technique. In the final phase, a multi-objective fuzzy–stochastic mathematical model was developed to design and optimize the supply chain network, while fuzzy–stochastic robust optimization was employed to address data uncertainty. The multi-objective problem was solved using a modified version of the lexicographic–Chebyshev multi-choice goal programming method (LCRMCGP).

Findings: A case study conducted in “Ebtakar Tajhiz Teb Yekta,” a company operating in the medical equipment industry, demonstrated that the proposed model effectively supports key strategic decisions, including the selection of primary and backup suppliers, the optimal location of collection and recycling centers, excess capacity allocation, and the choice of information-exchange technologies (traditional systems vs. blockchain-based platforms). The integration of IoT and blockchain technologies increased product return rates, reduced recycling costs, and enhanced transparency and sustainability across the network. Overall, the results confirm that the proposed framework can successfully balance economic, environmental, and social objectives while improving flexibility and resilience under uncertainty.

Originality/Value: The novelty of the present study lies in developing an integrated framework for designing a viable closed-loop supply chain under hybrid fuzzy–stochastic uncertainty. Unlike previous studies that mainly focused on isolated dimensions of supply chain management, this research simultaneously incorporates sustainability, resilience, agility, and digitalization within a multi-objective optimization model. Furthermore, the integration of SARIMA, SFBWM, SFTOPSIS, and LCRMCGP methods provides a more accurate and comprehensive decision-making process. Comparative results also demonstrate that the proposed model outperforms conventional approaches in reducing deviations, improving decision consistency, and enhancing overall network sustainability.